Dados do Trabalho

Título

Pro-atherogenic factors and sleep quality among women with severe obesity

Introdução

Cardiovascular diseases are the first cause of death in Brazil and as a multifactorial disease, many factors should be analyzed. Poor quality sleep is associated with coronary heart disease (CHD), inflammation and pro-coagulant factors. Plasminogen Activator Inhibitor-1 (PAI-1) can be a link between sleep characteristics and CHD, both factors elevated in severe obesity. Higher PAI-1 levels are related to higher sleep disorders by polysomnography, but more studies should analyze it with more applicable measurements.

Objetivo

The main of the study is to test the hypothesis that seric concentrations of PAI-1 in severe obese women is associated with impaired sleep evaluated by validated questionnaires.

Métodos

Forty-five women with severe obesity (BMI>40 kg/m²) at a public hospital were enrolled in this study, approved by Ethics Committe (961/19). The quality of sleep was analyzed by Pittsburgh Sleep Quality Index (PSQI) and Epworth sleepiness scale (ESS). Anthropometric measurements collected were: weight, height, neck (NC), waist (WC), and hip circumference (HC). Blood samples were collected to analyze the metabolic profile (glucose/lipid profile; c-reactive protein) and PAI-1 (determined by ELISA immunoassay). Statistical analyses were performed in SPSS. Normality was assessed by Shapiro Wilk Test. Generalized Linear Models (GLZM) was used to compare the groups and Spearman’s to verify the correlation between sleep disorders and others variables.The volunteers were grouped according the median of values of PAI-1.

Resultados

The mean age and BMI of the volunteers were 40,1 ± 8,5 years and 48,19 ± 7,05 kg/m², respectively. All the mean values of circumferences were compatible with cardiovascular risk. The prevalence of impaired sleep was 68,9% and 42,2% assessing PSQI and ESS. No correlation in sleep questionnaires and metabolic parameters were found. The group with high values of PAI-1 presented significant higher insulin and lower HDL, but any difference in sleep analyses was observed. In correlation analyses, the group with high levels of PAI-1 showed a correlation between PSQI and total cholesterol (r=0,503; p=0,033) and the group with low levels of PAI-1 showed a negative correlation between ESS and HDL (r=-0,481; p=0,023).

Conclusões

Both sleep parameters were correlated with pro-atherosclerotic lipid profile in patients with severe obesity. No difference between sleep quality was observed when analyzed by PAI-1 levels. Funding: CNPq/FUNAPE.

Palavras -chave

PAI-1, poor sleep quality, cardiovascular diseases.