Dados do Trabalho

Título

Sleep quality can affect the amount of adverse symptoms experienced by COVID-19 vaccines

Introdução

Vaccines for COVID-19 have caused several adverse effects, with those vaccinated reporting different numbers of symptoms (NS).

Objetivo

To verify whether lifestyle-related factors are associated with the NS due to the COVID-19 vaccine's first dose.

Métodos

We used Google Forms to collect information related to the vaccination period, such as sleep quality(Pittsburg questionnaire-PSQI), physical activity (IPAQ), diets, and alcohol intake. We also collect the type of vaccine taken, if they had COVID-19 or chronic medication use, age, sex, weight, and height.We used SPSS v.26 to perform a stepwise multiple linear regression (SMLR) using the NS as the dependent variable. The participants' lifestyle data and other individual characteristics were used as independent variables. Then we made a decision tree (DT) regression model (CHAID method) to explore the relationship between lifestyle and vaccine NS. The DT nodes (leaves) were pruned to compare at least 50 samples in each node. In the DT model, we used the NS as the dependent variable and lifestyle data as the independent variable.This study was approved by the Ethical Committee (nº: 0686P/2021).

Resultados

300 participants (age, 18 to 75 y old and both genders) answered the questionnaires and reported three types of vaccine that affected different NS (CoronaVAc= 0.9 NS, 95% CI= 0.6 to 1.2; Pfizer= 1.8 NS, 95% CI= 1.5 to 2.3. and; AstraZeneca= 3.9 NS, 95% CI= 3.5 to 4.3). Vaccine type and age were the only predictors that entered the SMLR model (adjusted R2=0.304; vaccine, B= 1.038, 95% CI= 9, 0.8 to 1.2; age, B= -0.054, 95% CI= -0.078 to -0.031; P=0.000). In the DT model, using age as a covariate, we identified that a change in sleep efficiency (SE) is related to the NS (ES <= 82.8%= 3.3 NS; ES% between 82.3 to 93.3%= 2.2 NS; ES> 93.3%= 2.8 NS; P=0.000). Medication used could decrease NS from 2.5 to 1.7 reports in the “82.3 to 93.3%” ES nodule. When using the vaccine type as a covariate, in the DT model, we observed that the PSQI score is related to different NS reports (PSQI score <= 3= 2.2 NS; a PSQI score >3= 3.4 NS). Also, the medication used could decrease the NS from 3.7 to 3 reports in the “PSQI score >3” nodule.

Conclusões

Considering age and type of vaccine, sleep quality significantly influences the number of adverse effects reported from participants who take the COVID-19 vaccine. Medications used can mitigate the NS reported by the participants.

Palavras -chave

Vaccine; COVID-19; Sleep.